Publications
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Full list of publications:
2022
Adapala, R.K., Kanugula, A.K., Ohanyan, V., Paruchuri, S., Chilian, W.M. and Thodeti, C.K. (2022) TRPV4 deletion in endothelium protects heart against pressure overload induced hypertrophy (In preparation for Nat Cardiovascular Sciences)
听Paek, J., Teegala, L.R., Alisafaei, F., Clair, G.C., Song, J.W., Park, S.E., Ansong, C.K., Mondrinos, M.J., Shenoy, V., Thodeti, C.K., Paruchuri, S., and Huh, D. (2022) Mechanically actuatable airway disease-on-a-chip: a novel platform to study biomechanical basis of obstructive human lung disease (In preparation for Nat Biotechnology)
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2021
Guarino, B., Katari, V., Adapala, R.K.., Bhavnani, N., Dougherty, J.A.,Khan, M.Paruchuri, S., and Thodeti, C.K. (2021) Tumor-derived extracellular vesicles induce abnormal angiogenesis via TRPV4 downregulation and subsequent activation of YAP and VEGFR2. Front Bioengg Biotechnol) 9:790489. doi: 10.3389/fbioe.2021.790489.
听Adapala, R., Katari, V., Teegala, L.R., Thodeti, S., Paruchur, S. and Thodeti, C.K. (2021) TRPV4 Mechanotransduction in Fibrosis. Cells 10(11):3053. doi: 10.3390/cells10113053.
听Pokhrel S, Gudneppanavar R, Teegala LR, Duah, E, Thodeti CK, and Paruchuri, S*. (2021) Leukotriene D4 upregulates oxidized low-density lipoprotein receptor 1 and CD36 to enhance oxidized LDL uptake 听听听 and phagocytosis in macrophages through Cysteinyl leukotriene receptor 1. Frontiers in Physiology. 12:756450. doi: 10.3389/fphys.2021.756450.
听Kanugula. A.K., Adapala, R.K., Jamaiyar, A., Lenkey, N., R, Guarino, B., Liedtke, W., Yin, L., Paruchuri, S. and Thodeti, C.K. (2021) Endothelial TRPV4 channel deletion promotes tumor growth and metastasisAngiogenesis doi: 10.1007/s10456-021-09775-9.)
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听2020
Cappelli, H., Guarino, B., Kanugula, A.K., Adapala, R.K., Perera, V., Smith, M., Paruchuri, S and Thodeti, C.K. (2020) Transient receptor potential vanilloid 4 channel deletion regulates pathological but not physiological retinal angiogenesis. J Cell Physiol Oct 20. doi: 10.1002/jcp.30116.
听Guarino, B., Paruchuri, S and Thodeti, C.K. (2020) Role of Transient receptor potential vanilloid 4 channels in ocular function. 听Exp. Eye Res. 201:108257.
听Adapala, R., Kanugula.A, Paruchuri, S., Chilian, W.M.and Thodeti, C.K. (2020) TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation Basic Res Cardiol 115(2):14. doi: 10.1007/s00395-020-0775-5.
听Al-Azzam, N., Teegala, L.R., Pokhrel, S., Ghebreigziabher, S., Chachkovskyy, T., Thodeti, S., Gavilanes, I., Covington, K., Thodeti, C.K. and Paruchuri, S (2020) Transient Receptor Potential Vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH Oxidase 4. Scientific Reports 10(1):9827.
听Kanugula, A., Adapala, R, Guarino, B., Bhavnani, B., Dudipala, H., Paruchuri, S., and 听听听听听Thodeti, C.K.* (2020). Methods for Studying Angiogenesis using Matrigel In Vitro and In Vivo. Methods in Molecular Biology.Volume: Vascular Permeability: Methods and Protocols. (Eds: Binu Tharakan). Springer Publications. In Press.
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2019
Guarino, B., Adapala, R.K.., Kanugula. A.K., Lenkey, N., Dougherty, J.A.,Paruchuri, S., Khan, M.and Thodeti, C.K. (2019) Extracellular vesicles from pathological microenvironment induce endothelial cell transformation and abnormal angiogenesis via modulation of TRPV4 channels (In review Front Cell Dev Biol 7:344. doi: 10.3389/fcell.2019.00344.
听Duah, E., Teegala, L.R., Kondeti, V., Adapala, R., Keshamouni, V., Kanaoka, Y., Austen, K.F., Thodeti, C.K. and Paruchuri, S (2019) Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis and metastasis. Proc Natl Acad Sci, USA116(1):199-204.
Cappelli, H.C., Kanugula, A.K., Adapala, R.K., Amin, V., Sharma, P., Paruchuri, S., and Thodeti, C.K. (2019)Mechanosensitive TRPV4 channels regulate tumor vascular integrity and metastasis through stabilization of VE-cadherin junctions. Cancer Lett 442:15-20.
Kanugula, A., Adapala, R., Midha, P., Cappelli, H., Meszaros, J.G., Paruchuri, S., Chilian, W.M. and Thodeti, C.K (2019). Novel non-canonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4. FASEB J 33(1):195-203. doi: 10.1096/fj.201800509R. [Epub ahead of print]
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2018
Paruchuri, S. and Thodeti, C.K. (2018) Form follows function: Polymorphisms in mAKAP alter cardiac cAMP/PKA signalling. Am J Physiol Heart Circ Physiol 315(3):H626-H628. doi: 10.1152/ajpheart.00248.2018. Epub 2018 May 4.
听Kanugula, A.K. and Thodeti, C.K. (2018) AMP-activated kinase 鈥淜eaps鈥� ischemia/reperfusion-induced necroptosis under control. International Journal of Cardiology 259:168-169.
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2017
Thodeti, C.K. (2017) Changing the Channels: Nature鈥檚 remote Controlling in Health and Disease. Circ Res 120(4):599-601.
听Gombedza, F., Kondeti, V., Al-Azzam, N.,听 Koppes, S., 听听Duah, E., Patil, P., Hexter, M., Phillips. D., Thodeti, C.K. and Paruchuri, S. (2017) Mechanosensitive transient receptor potential vanilloid4 regulates Dematophagoides farina-induced airway remodeling via two distinct pathways modulating matrix synthesis and degradation FASEB J. doi: 10.1096/fj.201601045R. [Epub ahead of print]
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