兔子先生传媒文化作品

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Department of Medicine

Endocrinology, Diabetes and Metabolism听Research

RESEARCH SUMMARY

Our group also conducts clinical/translational research at outpatient clinics and inpatient service sites within the University of Toledo Health Science Campus (University of Toledo Medical Center, Ruppert Health Center, Dana Cancer Center) and the ProMedica Health Campus (The Toledo Hospital and the Falzone Diabetes Center).听 Basic sciences research is conducted at the Center for Diabetes and Endocrine Research (CeDER) at the 兔子先生传媒文化作品 Health Science Campus.听

Scientifically, the Division鈥檚 research encompasses clinical, translational and basic science areas as described below:

Current Clinical/Translational projects include:

  1. Latent Autoimmune Diabetes of Adult Database Study (IRB approved)
  2. Anti-Program Cell Death-1 Pathway Blockade and Type 1 Diabetes Development (MEDTRONIC GRANT AWARD)听(IRB approved)
  3. Calcitonin Enhanced Localization of Parathyroid Adenomas听(IRB approved)
  4. Thyroid Nodule Database Study听(IRB approved)
  5. Insulin Antibodies and Insulin Resistance听(IRB approved)
  6. Glycemic Control with Digitally Coordinated Care in Type II Diabetic Populations (IRB approved)
  7. Low Dose CT and Adrenal Incidentalomas听(IRB approved)
  8. 厂骋尝罢2听Protracted Glycosuria (IRB pending)
  9. New Onset Diabetes After Transplant (NODAT, IRB pending)
  10. Glycemic variability during enteral nutrition (IRB pending)
  11. Inpatient Steroids and Diabetes Best Practice Alert (IRB pending)
  12. SDOH in Diabetes: Continuous Glucose Monitor Systems in underserved populations (QIP)

Current Basic/Translational projects include:

  1. Characterization of a New Humanized Transgenic Model of Type 1 Diabetes听(US Patent filed)
  2. Immunotherapeutic Treatments of Allo and Autoimmunity听听(International Patent filed-Business Incubator: AdopTracell庐)
  3. Thyroid Cancer Cellular Biomarkers听(US Patent filed)
  4. Tumor Immunity Induction Studies

For details on Division鈥檚 basic sciences research program go to:

Center for Diabetes and Endocrine Research (CeDER)

LabS WebsiteS

JOHN JUN LAB

Shahnawaz Imam LAB

Recent /relevant peer reviewed abstracts/papers (2015 to present)

  1. J. B. Hao, A. Schuna and J. C. Jaume. Extree Insulin Resistance from Insulin Antibodies (not Insulin Receptor Antibodies) Successfully Treated with Combination Immunosuppresive Therapy.听 The Endocrine Society.听 San Diego, CA 2015.
  2. S. Imam, R. Paparodis and J. C. Jaume.听 Does Macrophage Plasticity in Thyroid Microenvironment Decide the Fate of Thyroid cancer?听 The Endocrine Society.听 San Diego, CA 2015.
  3. R. Paparodis R and J. C. Jaume.听 Reanalysis of the data reveal even stronger associations between Hashimoto's thyroiditis and differentiated thyroid cancer.听 Thyroid. 2015;25:142
  4. J. B. Hao, S Thida, S Sirinvaravong, A Day and J. C. Jaume*.听 Early Adulthood Onset Diabetes: T1DM, T2DM, Latent Autoimmune Diabetes of Adults, does it really matter?听 The Endocrine Society.听 Boston, MA 2016.听 *Helmsley Charitable Abstract Award in T1D
  5. A. Renno, J.B. Hao, S. Imam, J.C. Jaume.听 An FDA Approve Drug that Causes Type 1 Diabetes.听 Is it Just Coincidence?听 The Endocrine Society.听 Boston, MA 2016.
  6. J. B. Hao, A. Renno, S. Imam, M. A. Alfonso-Jaume, N. Elnagar and J. C. Jaume.听 Development of Type 1 Diabetes after Cancer Immunotherapy. 听Endocr Pract Epub 2016.
  7. J. B. Hao, S. Imam, P. Dar, M. A. Alfonso-Jaume, N. Elnagar and J. C. Jaume. 听Extreme Insulin Resistance from Insulin Antibodies (Not Insulin Receptor Antibodies) Succesfully Treated with Combination Immunosuppressive Therapy.听Diabetes Care Epub 2016.
  8. R.D. Paparodis, D. Bantouna, S. Imam and J.C. Jaume.听The Risk of Thyroid Cancer Depends on the Type of Autoimmune Thyroid Disease Associated with It.听听The Endocrine Society.听听Orlando, FL 2017.
  9. G. Antoniou, S. Kasikis, C. Chourpiliadis, D. Bantouna, J.C. Jaume and R.D. Paparodis.听听Patients with History of Fractures Have Profound Abnormalities in Bone Metabolism and Thyroid Function.听听The Endocrine Society.听听Orlando, FL 2017.
  10. R.D. Paparodis, D. Bantouna, S. Imam and J.C. Jaume.听Higher Serum TSH Is Associated with Differentiated Thyroid Cancer Risk, Only in the Absence of Thyroid Autoimmunity.听The Endocrine Society.听听Orlando, FL 2017.
  11. S. Imam, P Dar, K. Almotah, R.D. Paparodis and J.C. Jaume.听听Macrophage-Natural Killer Cell Cross-Talk: Implications for Thyroid Cancer.听听The Endocrine Society.听听Orlando, FL 2017.
  12. R.D. Paparodis, D. Bantouna, S. Imam and J.C. Jaume.听Comparison of Features of Tumor Aggressiveness Between Thyroid Papillary Microcarcinomas and Macrocarcinomas.听听The Endocrine Society.听听Orlando, FL 2017.
  13. G. Antoniou, S. Kasikis, C. Chourpiliadis, D. Bantouna, J.C. Jaume and R.D. Paparodis.听听Biochemically Euthyroid Patients with Symptoms Attributable to Thyroid Disease, Have a High Prevalence of Abnormal Bone Density and Fractures.听听The Endocrine Society.听听Orlando, FL 2017.听
  14. M.S. Khan, J.B. Hao, F. Chaudhry, A. Tiwari, H. Sharma and J.C. Jaume.听听Response to IVIG Leads to Diagnosis of Stiff Person Syndrome in a Patient with Limbic Encephalitis and GAD65 Autoantibodies without Diabetes.听听The Endocrine Society.听听Orlando, FL 2017.
  15. J. B. Hao, S. Imam, P. Dar, M. A. Alfonso-Jaume, N. Elnagar and J. C. Jaume.听听Extreme Insulin Resistance from Insulin Antibodies (Not Insulin Receptor Antibodies) Successfully Treated with Combination Immunosuppressive Therapy.听听Diabetes Care. 2017 Feb;40(2):e19-e20听
  16. I.A. Hajam, P.A. Dar, S, Imam, J.C. Jaume JC and J.H. Lee.听听Bacterial flagellin-a potent immunomodulatory agent.听听Exp Mol Med. 2017 Sep 1;49(9):e373
  17. J. B. Hao, A. Renno, S. Imam, M. A. Alfonso-Jaume, N. Elnagar and J. C. Jaume.听听Development of Type 1 Diabetes after Cancer Immunotherapy.听听Endocr Pract Epub 2017听
  18. O. Oraibi, L.I. Wharry, A.A. Lynn, F. Chaudhry, J.C. Jaume, J.Y. Jun.听听A Case of Adrenal Malignant Pheochromocytoma Combined with Primary Malignant Lymphoma.听The Endocrine Society.听听Chicago, IL 2018
  19. S. Imam, K.I. Almotah, P. Dar, A.S. AlKhudhair, R. Lamendella, J.C. Jaume.听听Prolonged Nursing (late Weaning), Delays The Onset Of Type 1 Diabetes In The Genetic Susceptible Humanized Mouse Model Of T1D.听听The Endocrine Society.听听Chicago, IL 2018
  20. C.P. Chourpiliadis, G. Antoniou, S. Kasikis, P-C.P. Koukoutsidi, L-N. Diamantopoulos, D. Bantouna, J.C. Jaume, R. Paparodis.听听Fractures of Any Kind, at Any Age Predict Low Bone Mineral Density and Osteoporosis.听The Endocrine Society.听听Chicago, IL 2018
  21. S. Alhassan, M. Rudoni, J.C. Jaume.听听Prolonged Glucosuria After Discontinuation Sglt2 Inhibitors: Implications For Weekly Dosing And Extended Risk Of Euglycemic Diabetes Keto-acidosis.听听The Endocrine Society.听听Chicago, IL 2018
  22. R. Paparodis, D. Bantouna, S. Imam, J.C. Jaume.听The Impact of Follicular Variant Papillary Thyroid Cancer (FV-PTC) in Features of Tumor Aggressiveness in Thyroid Papillary Microcarcinomas and Macrocarcinomas.听听The Endocrine Society.听听Chicago, IL 2018
  23. S. Kasikis, G. Antoniou, P-C. P. Koukoutsidi, C.P. Chourpiliadis, D. Bantouna, M. Panagiota, J.C. Jaume, R. Paparodis.听听Bone Mineral Density Abnormalities in Patients with Biochemically Euthyroid Thyroiditis.听听The Endocrine Society.听听Chicago, IL 2018
  24. A. Tiwari, H. Al-Robeh, H Sharma, Z. Ammari, M. Saud Khan, J. C. Jaume.听听Steroid-induced diabetic ketoacidosis in patient with type 2 diabetes mellitus.听Endocr Pract Epub 2018
  25. Ammari Z, Pak SC, Ruzieh M, Dasa O, Tiwari A, Jaume JC, Alfonso-Jaume MA.听听Posttransplant Tacrolimus-Induced Diabetic Ketoacidosis: Review of the Literature.听Case Rep Endocrinol. 2018 May 9;2018:4606491.
  26. Imam S, Dar P, Paparodis R, Almotah K, Al-Khudhair A, Hasan SA, Salim N, Jaume JC.听 Nature of coexisting thyroid autoimmune disease determines success or failure of tumor immunity in thyroid cancer. 听J Immunother Cancer. 2019 Jan 7;7(1):3.
  27. Imam S, Prathibha R, Dar P, Almotah K, Al-Khudhair A, Hasan SA, Salim N, Jilani TN, Mirmira RG, Jaume JC.听 eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes.听 Sci Rep. 2019 Feb 7;9(1):1533.
  28. Paparodis RD, Bantouna D, Imam S, Jaume JC.听 The non-interventional approach to papillary thyroid microcarcinomas. An "active surveillance" dilemma.听 Surg Oncol. 2019 Jun;29:113-117.
  29. Pappada SM, Owais MH, Cameron BD, Jaume JC, Mavarez-Martinez A, Tripathi RS, Papadimos TJ.听 An Artificial Neural Network-based Predictive Model to Support Optimization of Inpatient Glycemic Control.听 Diabetes Technol Ther. 2020 Feb 6. doi: 10.1089/dia.2019.0252. [Epub ahead of print].
  30. Paparodis RD, Karvounis E, Bantouna D, Chourpiliadis C, Chourpiliadi H, Livadas S, Imam S, Jaume JC.听 Incidentally Discovered Papillary Thyroid Microcarcinomas Are More Frequently Found in Patients with Chronic Lymphocytic Thyroiditis Than with Multinodular Goiter or Graves' Disease.听 Thyroid. 2020 Feb 20. doi: 10.1089/thy.2019.0347. [Epub ahead of print]

Book Chapters

  1. J.C. Jaume.听听Endocrine autoimmunity.听听In Greenspan鈥檚 Basic & Clinical Endocrinology.听听10th ed. Gardner DG and Shoback DM, Eds. McGraw-Hill Medical, 2017, Chapter 2; pages 29-48 (Last 6 editions).
  2. H. Chen, D.F. Schneider, H. Mazeh, J.C. Jaume, S. Lubner.听听Cancer of the Endocrine System.听听In Abeloff鈥檚 Clinical Oncology.听听5th ed.听Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB and McKenna WG, Eds.听听Churchill Livingstone Elsevier, 2013, Chapter 71, pages听1112-1142.
  3. N. Elnagar, S. Alhassan, F. Khogeer, J. Jun, F. Chaudhry, M. Alfonso-Jaume, J.C. Jaume.听听The Noha (n蓹蕣 藞ha蕣) Manual of Inpatient Diabetes Management.听听Kindle Direct Publishing -Amazon.com, 2018.听

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