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University of Toledo Integrated Core Facilities (ICF)

David Weaver, D.D.S., Ph.D.

David Weaver, D.D.S., Ph.D. Assistant Professor
Office: 419.383.3402
Laboratory: 419.383.3402
贰尘补颈濒:听david.weaver@utoledo.edu

EDUCATION

B.S., Bowling Green State University, Bowling Green, OH, 1979
D.D.S., Ohio State University, Columbus, OH, 1984
Ph.D., Bowling Green State University, Bowling Green, OH, 1994

POSTGRADUATE TRAINING

  • Medical College of Ohio, Department of Dentistry, Toledo, OH 1984-1985
  • Medical College of Ohio, Department of Medicine, Toledo, OH 1995-2002
  • Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden, 1999

ACADEMIC APPOINTMENTS

  • 1995-2002: Senior Research Fellow, Department of Medicine, Medical College of Ohio, Toledo, OH
  • 1999: Personal Scholarship Recipient, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  • 2002-2017: Director, Genomics Core Laboratory, Program in Bioinformatics and Proteomics/Genomics, University of Toledo (formerly the Medical University of Ohio, formerly the Medical College of Ohio), Toledo, OH
  • 2002-2004: Assistant Professor (Research Track), Department of Physiology & Molecular Medicine, Medical College of Ohio, Toledo, OH
  • 2004-2005: Assistant Professor (Research Track), Department of Physiology & Cardiovascular Genomics (formerly Dept. of Physiology & Molecular Medicine), Medical College of Ohio, Toledo, OH聽
  • 2005-2006: Assistant Professor (Research Track), Department of Physiology & Cardiovascular Genomics, Medical University of Ohio (formerly Medical College of Ohio), Toledo, OH
  • 2006-2007: Assistant Professor (Research Track), Department of Physiology, Pharmacology, Metabolism & Cardiovascular Science (formerly Department of Physiology & Cardiovascular Genomics), Medical University of Ohio, Toledo, OH
  • 2007-2008: Assistant Professor (Research Track), Department of Physiology, Pharmacology, Metabolism & Cardiovascular Science, University of Toledo (formerly Medical University of Ohio), Toledo, OH
  • 2008-2010: Assistant Professor (Research Track), Department of Public Health and Homeland Security, University of Toledo, Toledo, OH
  • 2010-2013: Assistant Professor (Research Track), Department of Public Health and Preventive Medicine (formerly Dept. of Public Health and Homeland Security), University of Toledo, Toledo, OH
  • 2013-present: Assistant Professor (Research Track), Department of Surgery, University of Toledo, Toledo, OH
  • 2013-present: Director, Flow Cytometry Core Laboratory, Department of Surgery, University of Toledo, Toledo, OH

RESEARCH INTEREST

  • Flow cytometry usage in various research projects for determination of specific cell types. Sorting of human cells, bacteria, and algae/diatoms for experimentation.
  • Genomics, global gene expression, quantitative gene expression, carcinogenesis and mutagenesis

PUBLICATIONS (SELECTED)

  1. Weaver, D.A., Hei, T.K., Hukku, B., McRaven, J.A. and Willey, J.C., Cytogenetic and molecular genetic analysis of tumorigenic human bronchial epithelial cells induced by radon alpha particles, Carcinogenesis 18(6), 1251-1257, 1997.
  2. Willey, J.C., Crawford, E.L., Jackson, C.M.,聽Weaver, D.A., Hoban, J.C., Khuder, S.A. and DeMuth, J.P., Expression measurement of many genes simultaneously by quantitative RT-PCR using standardized mixtures of competitive templates, Am J Respir Cell Mol Biol 19(1), 6-17, 1998.
  3. DeMuth, J.P., Jackson, C.M.,聽Weaver, D.A., Crawford, E.L., Durzinsky, D.S., Durham, S.J., Zaher, A., Phillips, E.R., Khuder, S.A. and Willey, J.C., The gene expression index c-myc x E2F-1/p21 is highly predictive of malignant phenotype in human bronchial epithelial cells, Am J Respir Cell Mol Biol 19(1), 18-24, 1998.
  4. Weaver, D.A., Hei, T.K., Hukku, B., DeMuth, J.P., Crawford, E.L., McRaven, J.A., Girgis, S. and Willey, J.C., Localization of tumor suppressor gene candidates by cytogenetic and short tandem repeat analyses in tumorigenic human bronchial epithelial cell, Carcinogenesis 21(2), 205-211, 2000.
  5. Crawford, E.L., Peter, G.J, Noordhuis, P., Rots, M.G., Vondracek, M., Grafstr枚m, R.C., Lieuallen, K., Lennon, G., Zahorchak, R.J., Georgeson, M.J., Wali, A., Lechner, J.F., Fan, P.S., Kahaleh, M.B., Khuder, S.A., Warner, K.A.,聽Weaver, D.A., and Willey, J.C., Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR, Mol Diagn 6(4), 217-225, 2001.
  6. Vondracek, M.,聽Weaver, D.A., Sarang, Z., Hedberg, J.J., Willey, J.C., W盲rng氓rd, L. and Grafstr枚m, R.C., Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human and normal simian virus 40 T antigen-immortalized oral keratinocytes, Int J Cancer 99(6), 776-778., 2002.
  7. Weaver, D.A., Crawford, E.L., Warner, K.A., Elkhairi, F., Khuder, S.A. and Willey, J.C., ABCC5, ERCC2, XPA, and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines, Molecular Cancer 4(1):18, 2005.
  8. Weaver, D.A., Nestor-Kalinoski, A.L., Craig, K., Gorris, M., Parikh, T., Mabry, H., and Allison, D.C.聽聽Corrections for mRNA extraction and sample normalization errors find increased mRNA levels may compensate for cancer haplo-insufficiency, Genes Chromosomes Cancer 53, 194-210, 2014.
  9. Wu, X., Ren, G., Gunning III, W.T., Weaver, D.A.,Kalinoski, A.L., Kuder, S.A., Huntley, J.F. FmvB: a聽Francisella tularensismagnesium-responsive outer membrane protein that plays a role in virulence, PLoS One,聽11(8):聽2016.
  10. Weaver, D.A., Gopalakrishman, G., Joe, B., Large-scale transcriptome analysis, in聽Methods Molecular Biology, Hypertension Vol. 1527, (eds) R.M. Touyz and E.L. Schiffrin, Springer, New York, 1-26, 2017.