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University of Toledo Integrated Core Facilities (ICF)

Michael P. Morran, Ph.D.

Michael Morran, Ph.D. Research Assistant Professor
Department of Surgery, College of Medicine and Life Sciences
Office: 419.383.6028
贰尘补颈濒:听Michael.morran@utoledo.edu

EDUCATION

B.S., Biology, University of Toledo, Toledo, Ohio 2002
Ph.D., Medicinal Biological Chemistry, University of Toledo, Toledo, Ohio, 2006

POSTGRADUATE TRAINING

  • University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan 2007-2012

ACADEMIC APPOINTMENTS

  • 2002-2005: Teaching Assistant, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio听
  • 2002-2006: Research Assistant, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio听
  • 2007- 2012: Research Fellow, University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan听
  • 2012- 2014: Research Investigator, University of Michigan, Department of Internal Medicine, Ann Arbor, Michigan听
  • 2014- 2017: Research Assistant Professor, University of Toledo, Department of Medicinal Biological Chemistry, Toledo, Ohio
  • 2017-Present: Research Assistant Professor, University of Toledo, Department of Surgery, Toledo, Ohio

RESEARCH INTEREST

  1. My graduate and postgraduate researched was focused on understanding the mechanisms underlying the progression of the autoimmune disease Type-1 Diabetes.听听听听听听
  2. Currently, I am working on understanding the post injury signaling response, known as neointimal hyperplasia, which occurs within the vascular wall. 听

PUBLICATIONS

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  1. Mohammad MK*,听Morran MP*, Slotterbeck BD, Leaman DW, Sun Y, Grafestein H, Hong SC, and McInerney MF. 鈥淒yregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse.鈥澨�Int Immunol.听18(7): 1101-13, 2006.
  2. Morran MP, McInerney MF, and Pietropaolo M. 鈥淚nnate and Adaptive Autoimmunity in Type 1 Diabetes.鈥澨�Pediatr Diabetes.听听9(2): 152-61, 2008.
  3. Morran MP,Omen GS, Pietropaolo M. 鈥淚mmunology and genetics of type 1 diabetes.鈥澨�Mt Sinai J Med.听听75(4):听听314-27, 2008.
  4. McInerney MF, Alexander LA,听Morran MP听and Pietropaolo M. 鈥滻nnate Immunity, Toll-like Receptors, and Diabetes.鈥澨�Curr Immunol Rev2009, 5:111-121.
  5. Morran MP, Alexander LA, Slotterbeck BD, and McInerney MF. 鈥淒ysfunctional innate immune responsiveness to Porphyromonas gingivalis lipopolysaccharide in diabetes.鈥澨�Oral Microbiol Immunol. 24(4):听听331-9, 2009.
  6. Morran MP, Casu A, Arena VC, Pietropaolo S, Zhang YJ, Satin LS, Nelson P, Omenn GS, Trucco M, Becker DJ, and Pietropaolo M.听听鈥淗umoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes.鈥澨�Endocrinology. 151(6):听听2528-37, 2010.
  7. Bonner SM, Pietropaolo S, FanY, Chang Y, Sethupathy P,听Morran MP, Beems M, Pietropaolo M, et al. 鈥淪equence Variation in Promoter of Ica1 Gene, Which Encodes Protein Implicated in T1D, Causes Transcription Factor Autoimmune Regulator (AIRE) to Increase Its Binding and Down-regulate Expression.鈥澨�J Biol Chem.2012, 287(21):17882-93.
  8. Morran MP. 鈥淟engel鈥檚 Legacy鈥澨�The CrossFit JournalJan. 2013:听.
  9. Morran MP, Vonberg A, Khadra A, and Pietropaolo M. 鈥淚mmunogenetic of type 1 diabetes mellitus.鈥澨�Mol Aspects Med. 2015, 42: 42-60.
  10. Acevedo-Calado M, James EA,听Morran MP, Pietropaolo S, Ouyang Q, Arribas-Layton D, Songini M, Liguori M, Casu A, Auchus RJ, Huang S, Yu L, Michels A, Gianani R, Pietropaolo M. 鈥淚dentification of unique antigenic determinants in the amino-terminus of IA-2 (ICA512) in childhood and adult autoimmune diabetes: New Biomarker Development.鈥澨�Diabetes Care. 2017, 40(4):561-568.
  11. Morran MP, Al-Dieri A, Kalinoski A, Jordan RK, Gupta NK, McInerney MF. 鈥淚nsulin receptor based lymphocyte trafficking in the progression of type 1 diabetes.鈥澨�J Biol Methods. 2018, 5(1):e85.
  12. Acevedo-Calado MJ, Pietropaolo SL, Morran MP, Schnell S, Vonberg A, Verge CF, Gianani R,Becker DJ, Huang S, Greenbaum CJ, Yu L, Davidson HW, Michels AW, Rich SS, Pietropaolo M: Type 1 Diabetes TrialNet Study Group 鈥淎utoantibodies Directed to a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes.鈥� Diabetes. 2019 Sep;68(9):1819-1829.
  13. Nandedkar-Kulkarni N, Vartak AR, Sucheck SJ, Wall KA, Quinn A, Morran MP, McInerney MF: 鈥淒evelopment of a bioconjugate platform for modifying the immune response of autoreactive cytotoxic T lymphocytes involved in type 1 diabetes.鈥� Bioconjugate Chem. 2019, 30, 2049-2059.
  14. Gordon DM, Neifer KL, Hamoud AA, Hawk CF, Nestor-Kalinoski AL, SA Miruzzi, Morran MP, Adeosun SO, Sarver FG, Erhardt PW, McCullumsmith RE, Stec DE, Hinds TD: 鈥淏ilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor 伪鈥� JBC 2020, DOI: 10.1074/jbc.RA120.013700.
  15. Pollard CA, Morran MP, Nestor-Kalinoski AL: 鈥淭he COVID-19 pandemic: a globak health crisis.鈥� Physiol Genomics 2020, 52 (11) 549-557. https://doi.org/10.1152/physiolgenomics.00089.2020.
  16. Nandedkar-Kulkarni N, Esakov E, Gregg B, Atkinson MA, Rogers DG, Horner JD, Singer K, Lundy SK, Felton JL, Al-Huniti T, Nestor-Kalinoski AL, Morran MP, Gupta NK, Bretz JD, Balaji S, Chen T, McInerney MF: 鈥淚nsulin Receptor-Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice.鈥� J Immunol 2021, 206 (7) 1443-1453. DOI: https://doi.org/10.4049/jimmunol.1900357.
  17. Morgan EE, Morran MP, Horen NG, Weaver DA, Andrea L Nestor-Kalinoski AL: 鈥淩NO3 QTL Regulates Vascular Structure and Arterial Stiffness in the Spontaneously Hypertensive Rat.鈥� Physiol Genomics 2021, 1;53 (12):534-545. DOI: 10.1152/physiolgenomics.00038.2021.