William T. Gunning III, Ph.D.
Professor of Pathology
University of Toledo, College of Medicine
Mail Stop #1090 Health Sciences Campus
3000 Arlington Ave.
Toledo, OH. 43614-5804
Phone: 419-383-3752
Fax: 419-383-3066
Email: William.Gunning@utoledo.edu
Primary Responsibility
顿颈谤别肠迟辞谤,听Electron Microscopy Facility
Extramural Activity
Extensive involvement in the Microscopy Society of America (MSA)
Served as MSA President in 2008
Research/Scholarly Activities
Bleeding disorders/storage pool deficiencies
Virtual patients in medical education
Experimental carcinogenesis and chemoprevention
Recent Publications (for a complete list, click听):听
Samelson-Jones, B.J., Kramer,听P.M.,听Chicka, M.,听Gunning, W.T.,听Lambert, M.P.听听听MYH9-macrothrombocytopenia caused by a novel mutation (E1421K) initially presenting as apparent neonatal alloimmune thrombocytopenia.听听Pediatr Blood Cancer. 2017;:e26949.听听听听PMID: 29286575听听DOI:听听
听Mai, D.B., Smith, M.R., and听Gunning, W.T.听听Assessment of the Stability of von Willebrand Profile Clotting Factors and Platelet Dense Granule Testing Following Transport.听听Clinical and Applied Thrombosis/Hemostasis听听24(8):1261-1266, 2018.听听PMID: 30114934听听PMCID:听听
Srinath, M., Coberly, E., Ebersol, K., Lazuik, K., Bier, K,听Gunning, W.T., Hammer, R., Gruner, B, and Sathi, B.K.听听Refractory macrocytic anemia associated with ZRSR2 spliceosome mutation in Down Syndrome.听听Pediatric Hematology and Oncology, July, 2019.听听PMID: 31361176听听DOI:听
Gunning, W.T., Kvale, H., Kramer, P.M., Karabin, B.L., and Grubb, B.P.听听Postural Orthostatic Tachycardia Syndrome is Associated with Elevated G-Protein Coupled Receptor Autoantibodies.听听J Am Heart Assoc, 2019 Sep 17; 8(18):e013602; PMID:31495251听听PMCID:听听DOI:听
Riley, R.S.; Pai, S; Warmke, L.; Winkler, M.R.; Khan, A.; and听Gunning, W.T.听听A Case of Chronic Thrombocytopenia in a 17-Year-Old Female.听听Lab Med. 2019 Oct 10;50(4):406-420.听听PMID: 31361176听听DOI:听
Su, R.C., Lad, A., Breidenbach, J.D., Blomquist, T.M.,听Gunning, W.T., Dube, P., Kleinhenz, A.L., Malhotra, D., Haller, S.T., Kennedy, D.J.听听Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD).听听PLoS One. 2019 Dec 5;14(12):e0225604.. PMID: 31805072听听PMCID:听听DOI:听
Gunning, W.T., Raghavan, M., Calomeni, E.P., Turner, J.N., Roysam, B., Roysam, S., Smith, M.R., Kouides, P.A., and Lachant, N.A.听听A Morphometric Analysis of Platelet Dense Granules of Patients with Unexplained Bleeding: A New Entity of Microgranular Storage Pool Deficiency.听听J. Clin. Med. 2020, 9(6), 1734-; PMID:听32512725听听PMCID:听听听DOI:听
Zellner, B, Mengin-Lecreulx, D., Tulley, B.G.,听Gunning, W.T., and Booth, R., and Huntley, J.F.听听A Francisella tularensis L,D-carboxypeptidase plays important roles in cell morphology, envelope integrity, and virulence.听听Molecular Microbiology, 2021:1-22,听听听
Gunning, W.T., Stepkowski, M., Kramer, P.M., Karabin, B.L., and Grubb, B.P.听听Inflammatory Biomarkers in Postural Orthostatic Tachycardia Syndrome with Elevated G-Protein Coupled Receptor Autoantibodies.听听J. Clin. Med. 2021, 10(4), 623;听
Hummel, K., Meawad, H.,听Gunning, W.T., and Gohara, A.F.听听Negative Fat Pad Biopsy in Systemic AL: A Case Report Analyzing the Preferred Amyloidosis Screening Test.听听Diseases 2021, 9(1), 34071274 PMCID: PMC8161780 DOI: 10.3390/diseases9020040 听
Massey, G, Tyrell, L, Diab, Y. and听Gunning, W.T.听听Two Additional Cases of Medich Syndrome.听听(submitted to Platelets, December, 2020).
Gunning, W.T.,听Yoxtheimer, L., and Smith, M.R.听听Platelet Aggregation Assays Do Not Reliably Diagnose Platelet Delta Granule Storage Pool Deficiency.听听(in press, 2021, J Hematol).
Research Interests
Dr. Gunning's current research emphasis involves the study of bleeding diathesis specifically related to platelet dysfunction.听听He has evaluated patients with prolonged bleeding times and/or a history of bleeding including individuals that bruise easily and women with menorrhagia for more than 25 years.听听When tested for von Willebrand disease, these individuals are usually found to have normal aggregation responses or have a slight abnormality in response to epinephrine but not to ristocetin and are therefore, often a diagnostic enigma.听听His research utilizes a transmission electron microscope and computer analysis of platelets obtained from peripheral blood to determine the number and volume of delta granules (dense bodies) that contain important substances used for the effective coagulation of blood.听
Dr. Gunning has a number of collaborators throughout the country and the preliminary results of these studies suggests that delta granule storage pool deficiencies (未-SPD) may be a significant etiology of bleeding diathesis, especially in the case of menorrhagia.听听In addition, he has discovered a significant correlation with postural orthostatic tachycardia syndrome (POTS, a type of syncope) and 未-SPD.听听He has recently reported that POTS has a number of adrenergic and muscarinic receptor antibodies that suggest POTS is an autoimmune disease.听听He has also reported that POTS patients have elevations of a number of innate immune system cytokines and chemokines and is actively.听听He recently gave an invited presentation of unpublished data at Experimental Biology 2021.