兔子先生传媒文化作品

Randall G. Worth, Ph.D.

• Dean's Award for Teaching Excellence 鈥� University of Toledo College of Medicine and Life Sciences, 2008
• President's Award for Grantsmanship - University of Toledo, 2016

Lab Homepage

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• Platelets in inflammation and host defense against infections
• Mouse models of platelet activities
• Role of calcium waves in phagolysosome biogenesis

Dr. Worth is interested in the role of platelets in inflammation and infection. Two main projects are currently active to elucidate the immune function of platelets. First, Dr. Worth's laboratory has developed a conditional platelet-depletion mouse strain that is useful in studying the in vivo function of platelets during infections or other diseases. At a basic science level, Dr. Worth is interested in identifying pathways involved in pathogen destruction by platelets and leukocytes. His laboratory has identified certain membrane domains that participate in phagocytosis and may also be important in mediating phagosome-lysosome fusion. 听Dr. Worth also heads a translational project directed at understanding the role of platelets in autoimmune diseases (Systemic Lupus Erythematosus) and cancer. This project is revealing exciting new ways that platelets respond to IgG-complexes and the important interface between thrombosis and inflammation.听

Education

1992 - B.S. - Biology - University of Charleston, WV
1999 - Ph.D. - Biological Sciences - Wayne State University, Detroit, MI
2005 - Post-doctoral - Hematology & Oncology - Perelman School of Medicine, University of Pennsylvania

Current Grant Funding

NIDCR/NIH: 1RO1 DE027343: The role of platelets in protection against oral candidiasis (PI: Heather Conti, Co-I: Worth - 50%)

Book Chapter

Worth, R.G., A.D. Schreiber. Fc receptors and phagocytosis. In. Molecular Mechanisms of Phagocytosis. Landes Publishers.

Refereed Publications

39. Gautam, I., Huss, C.W., Storad, Z.A., Krebs, M., Bassiouni, O., Ramesh, R., Wuescher, L.M., Worth. R.G. 2023. Activated platelets mediate monocyte killing of Klebsiella pneumoniae. . doi.org/10.1128.iai.00556-22.

38. Connelly, M., Waites, S., Kaeley, D., Brewster, P., Sun, Z., Worth, R. 2023. Fit for health? Levels of physical activity among preclinical and clinical medical students. . doi.org/10.1177/15598276231161501

37. Meikle, CKS., Creeden, J.F., McCullumsmith, C., Worth, R.G. 2021. SSRIs: Applications in inflammatory lung disease and implications for COVID-19. doi: 10.1002/npr2.12194.

36. Shortridge, C., Akbari, F.E., Wuescher, L.M., Worth, R.G., Liberatore, M.W., Yildirim-Ayan, E. 2021. Impact of digestive inflammatory environment and genipin crosslinking on immunomodulatory capacity of injectable musculoskeletal tissue scaffold. .听

35. Gautam, I., Storad, Z., Filipiak, L., Huss, C., Meikle, C.K., Worth, R.G., Wuescher, L.M. 2020. From classical to unconventional: the immune receptors facilitating platelet responses to infection and inflammation. 听

34. Jordan, R.K., Shah, S.S., Desai, H., Tripi, J., Mitchell, A., Worth, R.G. 2020. Variation of stress levels, burnout, and resilience throughout the academic year in first-year medical students. .听

33. Meikle, C.K., Meisler, A.J., Bird, C.M., Jeffries, J.A., Azeem, N., Garg, P., Crawford, E.L., Kelly, C.A., Gao, T.Z., Wuescher, L.M., Willey, J.C., Worth, R.G. 2020. Platelet-T cell aggregates in lung cancer patients: Implications for thrombosis.

32. Martin, R.A., Buckley, K.H., Mankowski, D.C., Riley, B.M., Sidwell, A.N., Douglas, S.L., Worth, R.G., Pizza, F.X. 2020. Myogenic cell expression of intracellular adhesion molecule-1 (ICAM-1) contributes to muscle regeneration after injury. .

31. Schultz, C.M., Goel, A., Dunn, A., Knauss, H., Huss, C., Launder, D., Conti, H.R., Worth, R.G. 2020. Stepping up to the plate(let) against Candida albicans. .听doi: 10.1128/IAI.00784-19

30. Wuescher, LM., Nishat, N., Worth, R.G. 2019. Characterization of the PF4-DTR conditional chronic platelet depletion model. . 3:704-712.

29. Adams, S., Wuescher, L.M., Worth, R., Yildirim-Ayan, E. 2019. Mechano-Immunomodulation: mechanoresponsive changes in macrophage activity and polarization.. doi:10.1007/s10439-019-02302-4听

28. Nishat, S., Wuescher, L.M., Worth, R.G. 2018. Platelets enhance dendritic cell responses against S. aureus through CD40-CD40L interactions. . doi: 10.1128/IAI.00186-18听听

27. Meikle, C.K.S., Kelly, C.A., Garg, P., Wuescher, L.M., Ali, R.A., Worth, R.G. 2017. Cancer and Thrombosis: The Platelet Perspective. .听

26. Ali, R.A., Wuescher, L.M., Dona, K.R., Worth, R.G. 2017.听Platelets mediate host-defense against S. aureus through direct bactericidal activity and by enhancing macrophage activities. .

25. Ali, R.A., Wuescher, L.M., Worth, R.G. 2015. Platelets: essential components of the immune system. . 16:65-78.

24. Wuescher, L.M., Takashima, A., Worth, R.G. 2015.听A novel conditional platelet depletion mouse model reveals the importance of platelets in protection against S. aureus bacteremia. .

23. Dodd, D.A.,听Worth, R.G., Rosen, M.K.听, Grinstein, S.听, van Oers, N. S.C.听, Hansen,听E.J. 2014. The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase.听.

22. Cortes, C.,听Saggu, G.,听Emch, H.N.,听Ramirez, G.,听Worth, R.G.,听Ferreira,听V.P. 2013. Identification of a novel mode of complement activation on stimulated platelets mediated by properdin. .

21. Dearth, C.L, Goh, Q.,听Marino, J.S.,听Cicinelli, P.A.,听Torres-Palsa, M.J.,听Pierre, P.,听Worth, R.G.,听Pizza,F.X. 2013. Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response.听.听

20. Woodman, M.E.,听Worth, R.G., Wooten, R.M. 2012. Serum opsonization promotes the efficient uptake and killing of Burkholderia pseudomallei via induction of NADPH-oxidase by human neutrophils. .

19. Berlacher, M.D., Vieth, J.A., Heflin, B.C.,听Gay, S.R., Antczak, A.J., Singh, N., Montel, A.H., Kahaleh, M.B.,听Worth, R.G.听2013. Fc纬RIIa ligation induces platelet hypersensitivity to thrombotic stimuli. .

18. Vieth, J.A., Kim, M-k., Glaser,D., Stiles, K., Schreiber, A.D.,听Worth,R.G.听2013. Fc纬RIIa requires lipid rafts but not co-localization into rafts, for effector function. .

17. Riaz, A.H., Tasma, B.E., Woodman, M.E., Wooten, R.M.,听Worth, R.G.听2012. Human platelets efficiently kill IgG-opsonized E. coli. .听

16. Antczak, A.J., Vieth, J.A., Singh, N.,听Worth, R.G.听2011. Internalization of IgG-coated targets results in activation and secretion of soluble CD40 ligand and RANTES by human platelets. .

15. Vieth JA, Kim MK, Pan XQ, Schreiber AD,听Worth R.G.听2010. Differential requirement of lipid rafts for Fc纬RIIA mediated effector activities. .

14. Daniels, A.B.,听Worth, R.G., Dickstein, R.J., Dickstein, J.S., Kim-Han, T.H., Kim, M.K., Schreiber, A.D. 2010 Analysis of Fc纬RIIA cytoplasmic tail requirements in signaling for serotonin secretion: evidence for an ITAM-dependent, P13K-dependent pathway.听 .

13. Antczak, A.J., Singh, N., Gay, S.R.,听Worth, R.G.听 IgG-complex stimulated platelets: A source of sCD40L and RANTES in initiation of inflammatory cascase.听.

12.听Worth, R.G., C.D. Chien, P. Chien, M.P. Reilly, S.E. McKenzie S.E., A.D. Schreiber听 2006.听Platelet Fc纬RIIA binds and internalizes IgG-containing complexes.听 .听听听

11. Huang, Z.-Y.,听Barreda, Z.R.,听Worth, R.G.,听Indik, Z.K.,听Kim, M.K.,听Chien, P.,听Schreiber, A.D.听 2006. Differential kinase requirements in human and mouse Fc纬 receptor phagocytosis and endocytosis.听 .

10. Huang, Z.-Y.,听Hunter, S., Kim, M.-K., P.Chien,听Worth, R.G.,听Indik, Z.K., and听Schreiber, A.D. 听2004. The monocyte Fc纬 receptors Fc纬RI/纬 and Fc纬RIIA differ in their interaction with Syk and with Src-related tyrosine kinases.听 .

9.听Worth, R.G., Kim, M.-K.,听Jones, B.A.,听Daniels, A.B.,听Dickstein, R.,听Hunter, S.,听Chien, P.,听Schreiber, A.D. 听2003. Differing structural requirements for Fc纬RIIA mediated signaling events.听 Allergy Clin. Immunol. Int'l. Supplement 2, p197-200.听听听

8. Kim, M-K,听Hwang, P.-H.,听 Huang,听Z.-Y.,听Jones, B.A., Sato,听N.,听Hunter, S.听Kim-Han, T.-H,听听Worth, R.G.,听 Indik, Z.K.,听 Schreiber, A.D.听 2003.听 Signal sequence Fc纬 receptor transmembrane domains: Role in cell surface expression, gamma chain interaction and phagocytosis.听 .

7. *Worth, R.G., Kim, M-K., Kindzelskii, A.L.,听Petty, H.R.,听听Schreiber, A.D.听 2003.听听Signal sequence within Fc纬RIIA controls calcium wave propagation patterns: apparent role in phagolysosome fusion. . * Reviewed in Research Roundup, 鈥淐alcium waves in membrane fusion,鈥� .

6. Petty, H.R.,听Worth, R.G., Todd III, R.F. 听2002. Interactions of integrins with their partner proteins in leukocyte membranes.听 .

5.听Worth R.G., Mayo-Bond L, Kim MK, van de Winkel JG, Todd RF 3rd, Petty HR, Schreiber AD. 2001. The cytoplasmic domain of FcgammaRIIA (CD32) participates in phagolysosome formation.听.

4.听Worth, R.G.,听听Esper, R.M., Warra, N.S., Rosenspire, A.J., Todd, III, R.F., Petty, H.R.听听2001.听 Mercury inhibition of neutrophil activity: evidence of aberrant cellular signaling and incoherent cellular metabolism.听 .

3. Ben-Ozer, E.Y., Warra, N.S., Esper, R.M.,听Worth, R.G., Kindzelskii, A.L., McCabe, M.J., Rosenspire, A.J., Petty, H.R. 2000.听 Mercuric chloride damages cellular DNA by a non-apoptotic mechanism.听 .

2. Petty, H.R.,听Worth, R.G., Kindzelskii, A.L. 2000. Imaging sustained dissipative patterns in the metabolism of individual living cells. .

1.听Worth, R.G.,听Mayo-Bond, L.,听van de Winkle, J.G.J.,听Todd III, R.F., Petty, H.R. 1996. CR3 (伪m尾2; CD11b/CD18) restores IgG-dependent phagocytosis in transfectants expressing a phagocytosis defective Fc纬RIIA (CD32) tail minus mutant. .

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